Leukocytosis as a Predictor of Severe Injury in Blunt Trauma

Objective: The objective of this study was to determine if the white blood cell count can predict severity of injury in blunt trauma victims.Methods: This was a retrospective study comparing two groups of blunt trauma victims by severity of injury, one with significant injury and one without significant injury, and comparing their initial WBC in the emergency department (ED). We also examined if WBC correlates with degree of injury using Injury Severity Score (ISS) in both groups combined. Further, we examined the WBC as a predictor of serious injury.Results: Our study showed a difference in mean WBC between the two groups that was statistically significant (p<0.001). A positive relationship between ISS and WBC was found, although the association was weak (correlation coefficient = 0.369). While the WBC had moderate discriminatory capability for serious injury, it could not, in isolation, reliably rule in or out serious injury. Nevertheless, this study supports using WBC on presentation to the ED as an adjunct for making disposition decisions.Conclusion: A significant elevation in WBC in a blunt trauma patient, even with minimal initial signs of severe injury, should heighten suspicion for occult injury

More than antioxidant: N-acetyl-L-cysteine in a murine model of endometriosis

N-acetyl-L-cysteine exerts a complex action on endometrial cells, involving regulation of gene expression and protein activity and location, all converging into a decreased proliferation and a switch toward a differentiating, less invasive, and less inflammatory phenotype. Also considering the lack of undesired side effects, including unaffected fertility potential, this suggests a beneficial use of NAC in endometriosis clinical treatment. Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved

The Ursinus Weekly, January 8, 1962

Former Ursinusite, now Africa expert, to address Forum Wednesday night • Soc. classes hear prejudice speaker • Volunteer U.C. students pitch in at local Catholic boys\u27 protectory • Dr. Pancoast takes oath as mayor of Collegeville • President\u27s report reveals 1961 data, interesting facts • Fifty students attend open meeting; MSGA\u27s Moll airs campus problems • U.C. receives $2000 from Standard Oil • Delaware museum offers five grants • Day students tell Y of difficulties • Bill Scholl named to MAC first team • Eye surgery to be topic of next pre-med meeting • Singers choose Kershner 1962 business manager • Editorial: The right not to participate • Ursinus in the past • The New Lost City Ramblers at Haverford College • All Italian highways lead to Rome, the city of colorful contrasts • Twenty freshmen answer Weekly competition call • Cagers still seek win key; Losing streak at five games • Grapplers crunch Haverford, 31 to 3, in season\u27s opener • Freshman wrestler Fred Powers adds strength in the 157 lb. weight class • Ursinus again to host county science fairhttps://digitalcommons.ursinus.edu/weekly/1308/thumbnail.jp

Pleistocene/Holocene Cave Fossils From Grand Canyon National Park: Ice Age (Pleistocene) Flora, Fauna, Environments, and Climate of the Grand Canyon, Arizona

The Colorado Plateau is a distinct physiographic province in western North America covering an area of roughly 337,000 km2 (130,115 mi2) across parts of Arizona, Colorado, New Mexico, and Utah. Elevations range from about 360 m (1,180 ft) in the overall Grand Canyon (GC; which includes the Grand Canyon National Park, GRCA) river corridor to an average at the eastern South Rim of 2,072 m (6,800 ft) to 3,850 m (12,630 ft) on the nearby San Francisco Peaks at Flagstaff, Arizona, with an average elevation of 1,525 m (5,000 ft). The Colorado River of Grand Canyon is located along the southwestern portion of the Colorado Plateau in Arizona and is renowned for its dramatic display of geomorphic effects created by fluvial incision and its unique dry-preservation of fossils from the Ice Age (late Pleistocene and Holocene [Quaternary]; most recent 2.58 million years). Although there were at least 22 glacial-interglacial cycles during the Ice Age, this discussion is limited to the most recent episode (called the Wisconsinan Glaciation), which includes the transition to the modern climate (latest Pleistocene and Holocene; the most recent 50,000 years of geologic history)

Treatment of Periodontitis by Local Administration of Minocycline Microspheres: A Controlled Trial

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141491/1/jper1535.pd

Evaluation of a student-run smoking cessation clinic for a medically underserved population

<p>Abstract</p> <p>Background</p> <p>Smoking is common among medically underserved populations. Accessible resources to encourage and support smoking cessation among these patients are limited. Volunteer medical student-run free smoking cessation clinics may provide an effective option to help these individuals achieve smoking abstinence. In order to demonstrate the feasibility and cost-effectiveness of a student-run clinic, we analyzed a case series of patients receiving care in a medical student-run Smoking Cessation Clinic (SCC) at the Rochester, Minnesota Salvation Army Good Samaritan Health Clinic (GSHC).</p> <p>Findings</p> <p>Between January 2005 and March 2009, 282 cigarette smokers seeking care at the SCC were analyzed. Student providers at the SCC conducted 1652 weekly individual counseling sessions averaging 18 minutes per encounter. Patients were offered a choice of pharmacotherapies including nicotine replacement therapy (NRT), bupropion, and varenicline for up to 12 weeks. Smoking abstinence was confirmed with exhaled carbon monoxide (CO). Thirty-two patients completed the entire 12-week program (11.3%). At last contact, 94 patients (33.3%) abstained from smoking for ≥ 7 days and 39 patients (13.8%) were continuously abstinent for ≥ 4 weeks. The 7-day point prevalence abstinence rates at last contact were 58.6% for varenicline, 41.2% for bupropion, 33.9% for NRT, and 23.5% for bupropion and NRT. Analyzing missing patients as smoking, the 7-day point prevalence abstinence rates were 7.1%, 8.9%, and 8.2%, at 1 month, 2 months, and 3 months after program enrollment, respectively. No serious adverse drug reactions were recorded.</p> <p>Conclusions</p> <p>Our medical student-run smoking cessation clinic provided an effective and safe experience for medically underserved patients who might not otherwise have access to conventional smoking cessation programs because of high cost, lack of insurance, or other disparities. Similar medical student initiatives focusing on healthy lifestyles may be feasible and beneficial for individuals with limited access to healthcare resources.</p

Long-Baseline Neutrino Facility (LBNF) and Deep Underground Neutrino Experiment (DUNE) Conceptual Design Report Volume 2: The Physics Program for DUNE at LBNF

The Physics Program for the Deep Underground Neutrino Experiment (DUNE) at the Fermilab Long-Baseline Neutrino Facility (LBNF) is described

Monosodium urate crystals promote innate anti-mycobacterial immunity and improve BCG efficacy as a vaccine against tuberculosis

A safer and more effective anti-Tuberculosis vaccine is still an urgent need. We probed the effects of monosodium urate crystals (MSU) on innate immunity to improve the Bacille Calmette-Guerin (BCG) vaccination. Results showed that in vitro MSU cause an enduring macrophage stimulation of the anti-mycobacterial response, measured as intracellular killing, ROS production and phagolysosome maturation. The contribution of MSU to anti-mycobacterial activity was also shown in vivo. Mice vaccinated in the presence of MSU showed a lower number of BCG in lymph nodes draining the vaccine inoculation site, in comparison to mice vaccinated without MSU. Lastly, we showed that MSU improved the efficacy of BCG vaccination in mice infected with Mycobacterium tuberculosis (MTB), measured in terms of lung and spleen MTB burden. These results demonstrate that the use of MSU as adjuvant may represent a novel strategy to enhance the efficacy of BCG vaccination

The Role of Galectin-1 and Galectin-3 in the Mucosal Immune Response to Citrobacter rodentium Infection

Despite their abundance at gastrointestinal sites, little is known about the role of galectins in gut immune responses. We have therefore investigated the Citrobacter rodentium model of colonic infection and inflammation in Galectin-1 or Galectin-3 null mice. Gal-3 null mice showed a slight delay in colonisation after inoculation with C. rodentium and a slight delay in resolution of infection, associated with delayed T cell, macrophage and dendritic cell infiltration into the gut mucosa. However, Gal-1 null mice also demonstrated reduced T cell and macrophage responses to infection. Despite the reduced T cell and macrophage response in Gal-1 null mice, there was no effect on C. rodentium infection kinetics and pathology. Overall, Gal-1 and Gal-3 play only a minor role in immunity to a gut bacterial pathogen